Recent Articles and Videos
·
Biofilms and
Chronic Infections.
Wolcott and Ehrlich published in the Journal of the American Medical Association. June 11, 2008.
Introduces
the concept that all chronic infections should be viewed as medical biofilm
disease. By grouping all chronic
infections under one category (much like cancers are grouped under one category)
diagnoses and management of chronic infections will be improved.
·
A Study of
Biofilm-Based Wound Management in Subjects with Critical Limb Ischaemia.
Wolcott and Rhoads published in the Journal of Wound Care. April
2008.
By
targeting biofilm as a major barrier to wound healing, there is a statistically
significant increase in the percentage of wounds healed compared with standard
methods. See the 190 cases.
James, Swogger, Wolcott, Pulcini, Secor, Sestrich, Costerton,
and Stewart published in Wound Repair and
Regeneration. Jan-Feb 2008.
Biofilm
is polymicrobial and prominent on the wound beds of chronic wounds. Acute wounds showed no significant biofilm.
·
Biofilm and
Chronic Wound Inflammation.
Wolcott, Rhoads, and Dowd published in the Journal of
Woundcare. August 2008.
Gives a detailed molecular explanation
how biofilm can produce hyper inflammation at the site of a chronic wound so
that it can sustain and perpetuate itself.
Biofilm infections such as chronic wounds are best understood as
parasitic processes rather than predatory.
·
Interview with Dr. Randall Wolcott,
Bacterial Biofilm Wound Specialist.
Proal
published in Bacteriality. April 18, 2008.
This
interview explores, in layman’s terms, the role of biofilm in the growing
epidemic of chronic wounds throughout the world.
·
Conference
Session: Biofilms in Wounds.
Schultz and Wolcott presented at WOCN Conference 2007. June 10, 2007.
This
conference session was dedicated to demonstrating the biochemistry and
cellularity of all chronic wounds which is best explained by the presence of
biofilm and its production of a hyper inflammatory state.
Dowd, Sun, Secor, Rhoads, B.Wolcott, James and R.Wolcott published in BMC Microbiology. March 6,
2008.
Pyrosequencing
is a powerful tool for determining the species in a chronic infection such as
chronic wounds. Pyrosequencing was much
more sensitive than DGGE and was validated by the Sanger method.
This landmark
article was most viewed in BMC
Microbiology (March 2008).
·
Role of
Maintenance Debridement in the Treatment of Difficult-to-Heal and Chronic
Wounds.
Falanga, Brem, Ennis, Wolcott,
Gould, and Ayello published in Ostomy
Wound Management. June 2008
Supplement.
Demonstrates
a remarkable amount of agreement for the role of the debridement in management
of chronic wounds. Clearly debridement
is an important and foundational tool for managing chronic wounds.
·
Polymicrobial
Nature of Chronic Diabetic Foot Ulcer Biofilm Infections.
Dowd, Wolcott, Sun, McKeehan, Smith, and Rhoads
published in PlosOne. Oct. 3, 2008.
Demonstrates,
by deeply sequencing individuals with diabetic foot ulcers, that an incredible
number of different species of bacteria have been identified. We have been able to group certain species of
bacteria together in the functional equivalent pathogroups, or groups of
bacteria, that congregate to cause the inflammation necessary for the
maintenance of a chronic wound.
·
Evaluation of the Bacterial Diversity
in Feces.
Dowd, Callaway, Wolcott, Sun,
McKeehan, Hagevoort, and Edrington published in BMC Microbiology. July 24,
2008.
Our
454 pyrosequencing technology is now being applied to animal sciences to
understand the diversity of the GI tract.
·
Bacterial
Tag-Encoded FLX Amplicon Pyrosequencing for Microbiome Studies.
Dowd, Sun, Wolcott, Domingo,
and Carroll published in Foodborne
Pathogens and Disease. August 2008.
Proves
the concept that pyrosequencing could be used to understand the different
species inhabiting a wound, GI tract or any host environment.
·
Lactoferrin Study Results.
October 2, 2006.
·
MSU Wins
Millions to Find Treatments for Slow-Healing Wounds.
Ellig published in Montana State University Mountains & Minds. July 19, 2006.
Southwest Regional Wound Care Center, in conjunction
with Montana State University’s Center for Biofilm Engineering, receives a
grant from NIH to study biofilms.
March 10, 2006.
·
Video: Wound Bed Depth of Hip Wound.
February 9, 2006.
·
Video: Wound Depth and Bone Removal from Toe.
February 3, 2006.
·
Video: Wound Depth and Bone Removal from Hip.
February 3, 2006.
Randall Wolcott, M.D.,P.A.
2002 Oxford Lubbock, TX 79410
Phone: (806)793-8869 Fax:(806) 793-0043